Identification of agrin in electric organ extracts and localization of agrin-like molecules in muscle and central nervous system.

@article{Smith1987IdentificationOA,
  title={Identification of agrin in electric organ extracts and localization of agrin-like molecules in muscle and central nervous system.},
  author={Martin A. Smith and Yongming Yao and Noreen E Reist and Clint W. Magill and Bruce G. Wallace and Uel Jackson McMahan},
  journal={The Journal of experimental biology},
  year={1987},
  volume={132},
  pages={223-30}
}
The portion of the muscle fibre's basal lamina that occupies the synaptic cleft at the neuromuscular junction contains molecules that cause the aggregation of acetylcholine receptors and acetylcholinesterase on regenerating muscle fibres. Agrin, which is extracted from basal lamina-containing fractions of the Torpedo electric organ and causes the formation of acetylcholine receptor and acetylcholinesterase aggregates on cultured myotubes, may be similar, if not identical, to the acetylcholine… CONTINUE READING
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