Identification of acute myeloid leukemia in dogs using flow cytometry with myeloperoxidase, MAC387, and a canine neutrophil-specific antibody.

@article{Villiers2006IdentificationOA,
  title={Identification of acute myeloid leukemia in dogs using flow cytometry with myeloperoxidase, MAC387, and a canine neutrophil-specific antibody.},
  author={Elizabeth Villiers and Stephen Grant Baines and A Law and Victoria Mallows},
  journal={Veterinary clinical pathology},
  year={2006},
  volume={35 1},
  pages={55-71}
}
BACKGROUND Flow cytometry may be used to determine immunophenotype or lineage of leukemic cells, but few antibodies are available that are specific for cells of monocytic and granulocytic lineage. OBJECTIVE The purpose of this study was to evaluate the flow cytometric staining patterns of 3 commercial monoclonal antibodies for monocytes and granulocytes in clinically healthy dogs and in dogs with acute myeloid leukemia (AML). METHODS Mouse antihuman macrophage antibody (MAC387), mouse anti… CONTINUE READING

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