Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis.

@article{Douville2011IdentificationOA,
  title={Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis.},
  author={Ren{\'e}e Douville and Jiankai Liu and Jeffrey R Rothstein and Avindra Nath},
  journal={Annals of neurology},
  year={2011},
  volume={69 1},
  pages={141-51}
}
OBJECTIVE Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, of unknown etiology. Previous studies showed reverse transcriptase in serum of ALS patients at levels comparable to human immunodeficiency virus-infected patients; however, the source and significance of the retroviral elements is uncertain. METHODS Expression of a human endogenous retrovirus (HERV-K) was determined in autopsy brain tissue of patients with ALS and compared to control… CONTINUE READING
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