Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2.

@article{Doray2008IdentificationOA,
  title={Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2.},
  author={B{\'e}r{\'e}nice Doray and Jane M. Knisely and Lukas D Wartman and Guojun D Bu and Stuart Kornfeld},
  journal={Traffic},
  year={2008},
  volume={9 9},
  pages={
          1551-62
        }
}
The Golgi-localized, gamma-ear-containing, ADP ribosylation factor-binding family of monomeric clathrin adaptors (GGAs) is known to bind cargo molecules through short C-terminal peptide motifs conforming to the sequence DXXLL (X = any amino acid), while the heterotetrameric adaptors AP-1 and AP-2 utilize a similar but discrete sorting motif of the sequence [D,E]XXXL[L,I]. While it has been established that a single cargo molecule may contain either or both types of these acidic cluster… CONTINUE READING
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