Identification of a variant associated with adult-type hypolactasia

@article{Enattah2002IdentificationOA,
  title={Identification of a variant associated with adult-type hypolactasia},
  author={Nabil Sabri Enattah and Timo Sahi and Erkki Savilahti and Joseph D. Terwilliger and Leena Peltonen and Irma J{\"a}rvel{\"a}},
  journal={Nature Genetics},
  year={2002},
  volume={30},
  pages={233-237}
}
Adult-type hypolactasia, also known as lactase non-persistence (lactose intolerance), is a common autosomal recessive condition resulting from the physiological decline in activity of the lactase-phlorizin hydrolase (LPH) in intestinal cells after weaning. LPH hydrolyzes lactose into glucose and galactose. Sequence analyses of the coding and promoter regions of LCT, the gene encoding LPH, has revealed no DNA variations correlating with lactase non-persistence. An associated haplotype spanning… Expand
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