Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

@article{Kang1995IdentificationOA,
  title={Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.},
  author={X Q Kang and Yutaka Kawakami and Mona El-Gamil and R F Wang and Kazuyasu Sakaguchi and John R. Yannelli and Ettore Appella and Steven A Rosenberg and Paul F. Robbins},
  journal={Journal of immunology},
  year={1995},
  volume={155 3},
  pages={1343-8}
}
A number of Ags recognized by class I-restricted, melanoma-specific T cells have recently been identified. In this report we demonstrated that tumor-infiltrating lymphocytes (TIL) from melanoma patient 1413 recognize a tumor Ag, tyrosinase, in the context of HLA-A24. This Ag had previously been shown to be recognized by an HLA-A24-restricted TIL, TIL 888, as well as HLA-A2-restricted, melanoma-specific T cells isolated from two additional patients. The peptide epitope recognized by TIL 1413 was… CONTINUE READING

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