Identification of a two-loci epistatic interaction associated with susceptibility to rheumatoid arthritis through reverse engineering and multifactor dimensionality reduction.

@article{Juli2007IdentificationOA,
  title={Identification of a two-loci epistatic interaction associated with susceptibility to rheumatoid arthritis through reverse engineering and multifactor dimensionality reduction.},
  author={Antonio Juli{\`a} and J. Moore and Laia Miquel and Cayetano Alegre and Pere Barcel{\'o} and Marylyn DeRiggi Ritchie and Sara Marsal},
  journal={Genomics},
  year={2007},
  volume={90 1},
  pages={6-13}
}
Altered synovial fibroblast (SF) transcriptional activity is a key factor in the disease progression of rheumatoid arthritis (RA). To determine the transcriptional regulatory network associated with SF response to an RA proinflammatory stimulus we applied a CARRIE reverse engineering approach to microarray gene expression data from SFs treated with RA synovial fluid. The association of the inferred gene network with RA susceptibility was further analyzed by a case-control study of promoter… CONTINUE READING

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