Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

@article{Poschke2016IdentificationOA,
  title={Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.},
  author={Isabel Poschke and Marta Faryna and Frank Thomas Bergmann and Michael Flossdorf and Claudia Lauenstein and Jennifer Hermes and U. G. Hinz and Thomas Hank and Roland Ehrenberg and Michael Volkmar and Martin L{\"o}wer and Hanno Glimm and Thilo Hackert and Martin R Sprick and Thomas H{\"o}fer and Andreas Trumpp and Niels Halama and Jessica C Hassel and Oliver Strobel and Markus W. B{\"u}chler and Ugur Sahin and Rienk Offringa},
  journal={Oncoimmunology},
  year={2016},
  volume={5 12},
  pages={e1240859}
}
PURPOSE The devastating prognosis of patients with resectable pancreatic ductal adenocarcinoma (PDA) presents an urgent need for the development of therapeutic strategies targeting disseminated tumor cells. Until now, T-cell therapy has been scarcely pursued in PDA, due to the prevailing view that it represents a poorly immunogenic tumor. EXPERIMENTAL… CONTINUE READING