Identification of a thrombin receptor with factor Xa receptor and tissue factor in human pancreatic carcinoma cells.

@article{Kakkar1995IdentificationOA,
  title={Identification of a thrombin receptor with factor Xa receptor and tissue factor in human pancreatic carcinoma cells.},
  author={Ajay Kakkar and Nicholas R. Lemoine and Stuart R. Stone and Dario C. Altieri and Robin C. N. Williamson},
  journal={Clinical molecular pathology},
  year={1995},
  volume={48 5},
  pages={M288-90}
}
Venous thromboembolism is a common feature of pancreatic cancer. The underlying mechanism is unclear, but is likely to involve thrombin generation on the cell surface. Human pancreatic carcinoma cell lines (n=8) have been studied immmunohistochemically for the expression of tissue factor, factor Xa receptor, and thrombin receptor. Each antigen had a distinct pattern of immunoreactivity in cell membrane and cytoplasm. Tissue factor was predominantly localised to the membrane, whereas thrombin… CONTINUE READING

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