Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.

@article{Heinonen1999IdentificationOA,
  title={Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.},
  author={Petri Heinonen and Markku Koulu and Ullamari Pesonen and Matti K. Karvonen and Aila M. Rissanen and Markku Laakso and Raisa Valve and Matti Uusitupa and Mika Scheinin},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 7},
  pages={2429-33}
}
The alpha2-adrenergic receptors mediate part of the actions of the catecholamines noradrenaline and adrenaline on the regulation of energy balance. As part of an ongoing study on the genetics of obesity, the entire coding sequence of the alpha2B-adrenoceptor gene was screened in 58 obese, nondiabetic Finns by PCR-single stranded conformational analysis (PCR-SSCA). A polymorphism that leads to a deletion of 3 glutamic acids from a glutamic acid repeat element (Glu x 12, amino acids 297-309… CONTINUE READING