Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation.

@article{Cebrat2005IdentificationOA,
  title={Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation.},
  author={Malgorzata Cebrat and Arkadiusz Miazek and Pawel Kisielow},
  journal={European journal of immunology},
  year={2005},
  volume={35 7},
  pages={
          2230-8
        }
}
Recombination-activating gene (RAG)1 and RAG2 encode T and B lymphocyte-specific endonucleases indispensable for rearrangements of antigen-receptor gene segments but also capable of causing deleterious chromosome rearrangements. The mechanisms regulating RAG expression and repression are not clear. Here we identify NWC, a third evolutionarily conserved gene within the RAG locus, and show that it is ubiquitously expressed, with the notable exception of RAG-nonexpressing immature and mature T and… CONTINUE READING

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