Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.

@article{Asaoka2010IdentificationOA,
  title={Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.},
  author={Yoshinari Asaoka and Fumihiko Kanai and Tohru Ichimura and K Nakamura Tateishi and Yasuo Tanaka and Miki Ohta and Motoko Seto and Motohisa Tada and Hideaki Ijichi and Tsuneo Ikenoue and Takao Kawabe and Toshiaki Isobe and Michael B. Yaffe and Masao Omata},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 6},
  pages={4185-94}
}
Gli transcription factors are central effectors of Hedgehog signaling in development and tumorigenesis. Using a tandem affinity purification (TAP) strategy and mass spectrometry, we have found that Gli1 interacts with 14-3-3epsilon, and that Gli2 and Gli3 also bind to 14-3-3epsilon through homologous sites. This interaction depends on their phosphorylation, and cAMP-dependent protein kinase (PKA), a known negative regulator of Hedgehog signaling serves as a responsible kinase. A Gli2 mutant… CONTINUE READING
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