Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy.

@article{Fowble1988IdentificationOA,
  title={Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy.},
  author={Barbara L Fowble and Richard Dawson Gray and Kennedy W. Gilchrist and Robert L. Goodman and Samuel G. Taylor and Douglass C. Tormey},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1988},
  volume={6 7},
  pages={1107-17}
}
Risk factors for isolated local-regional (LR) recurrence following mastectomy for breast cancer were analyzed in a review of 627 women entered into Eastern Cooperative Oncology Group (ECOG) adjuvant chemotherapy trials between 1978 and 1982. Premenopausal patients were randomized to cyclophosphamide, methotrexate, and fluorouracil (5-FU) (CMF), cyclophosphamide, methotrexate, 5-FU, and prednisone (CMFP), or cyclophosphamide, methotrexate, 5-FU, prednisone, and tamoxifen (CMFPT). Postmenopausal… CONTINUE READING

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