Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta.

@article{Abdulovic2007IdentificationOA,
  title={Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta.},
  author={Amy L. Abdulovic and Brenda K. Minesinger and Sue Jinks-Robertson},
  journal={DNA repair},
  year={2007},
  volume={6 9},
  pages={
          1307-18
        }
}
Translesion synthesis (TLS) DNA polymerases are specialized to bypass lesions that block replicative polymerases and prevent complete genome duplication. Current TLS models hypothesize that PCNA, the polymerase processivity clamp, is important for regulating the access and loading of the low fidelity TLS polymerases onto DNA in response to replication-blocking lesions. PCNA binds to the C-terminus of yeast Poleta, for example, and this interaction is required for cell survival after UV… CONTINUE READING

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