Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.

@article{Nakao1994IdentificationOA,
  title={Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.},
  author={Shoichiro Nakao and Hiroyuki Takamatsu and Tatsuya Chuhjo and Masuzu Ueda and Shintaro Shiobara and Tamotsu Matsuda and Toshihiko Kaneshige and Hideaki Mizoguchi},
  journal={Blood},
  year={1994},
  volume={84 12},
  pages={4257-61}
}
Hematopoietic function of some aplastic anemia (AA) patients is dependent on the administration of cyclosporine (CyA). To investigate whether certain HLA class II genes are associated with susceptibility to such CyA-dependent AA, we determined the HLA class II alleles of 59 AA patients treated with CyA. Among 26 patients successfully treated with CyA, 13 required a small dose of CyA to maintain stable hematopoiesis. Of these 13 AA patients, 10 shared an HLA class II haplotype of DRB1*1501-DQA1… CONTINUE READING
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