Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis.

@article{Stterlin1997IdentificationOA,
  title={Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis.},
  author={Christine S{\"u}tterlin and Anna Horv{\'a}th and Peter Gerold and Ralph T. Schwarz and Yanzhuang Wang and Michael Morris Dreyfuss and Howard Riezman},
  journal={The EMBO journal},
  year={1997},
  volume={16 21},
  pages={
          6374-83
        }
}
Glycosylphosphatidylinositol (GPI)-anchoring represents a mechanism for attaching proteins to the cell surface that is used among all eukaryotes. A common core structure, EthN-P-Man3-GlcN-PI, is synthesized by sequential transfer of sugars and ethanolamine-P to PI and is highly conserved between organisms. We have screened for natural compounds that inhibit GPI-anchoring in yeast and have identified a terpenoid lactone, YW3548, that specifically blocks the addition of the third mannose to the… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Similar Papers

Loading similar papers…