Identification of a sorting signal for the regulated secretory pathway at the N-terminus of pro-opiomelanocortin.

@article{Cool1994IdentificationOA,
  title={Identification of a sorting signal for the regulated secretory pathway at the N-terminus of pro-opiomelanocortin.},
  author={David R. Cool and Yoke Peng Loh},
  journal={Biochimie},
  year={1994},
  volume={76 3-4},
  pages={265-70}
}
The N-terminal 26 amino acids of the prohormone pro-opiomelanocortin (POMC) were investigated to determine whether this region has the capacity to act as a sorting signal for the regulated secretory pathway. Constructs were made using the N-terminal 101, 50, 26 or 10 amino acids of POMC fused to the chloramphenicol acetyltransferase (CAT) reporter protein and expressed in AtT20 cells to show that at least the first 26 amino acids were required to sort CAT to the regulated secretory pathway… CONTINUE READING

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