Identification of a small peptide that inhibits the phosphorylation of ErbB2 and proliferation of ErbB2 overexpressing breast cancer cells.

@article{Pero2004IdentificationOA,
  title={Identification of a small peptide that inhibits the phosphorylation of ErbB2 and proliferation of ErbB2 overexpressing breast cancer cells.},
  author={Stephanie C. Pero and Girja S. Shukla and Ann Louise Armstrong and Daniel Peterson and Susan P. Fuller and Katherine S. Godin and Sarah L. Kingsley-Richards and Donald L. Weaver and Jeffrey P. Bond and David N Krag},
  journal={International journal of cancer},
  year={2004},
  volume={111 6},
  pages={
          951-60
        }
}
ErbB2 is overexpressed in approximately 30% of breast cancer patients with a correlation to poor prognosis. ErbB2 has been identified as a useful receptor for molecular targeting. A cyclic 20 amino acid phage display random peptide library was constructed using the fUSE5 gene III system. The library was panned against 2 different purified forms of the external domain of ErbB2. This resulted in the identification of several ErbB2-binding phage clones with variable binding to different ErbB2… CONTINUE READING
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