Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

@article{Wardman2016IdentificationOA,
  title={Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake},
  author={J. Wardman and I. Gomes and E. Bobeck and Jennifer A. Stockert and Abhijeet Kapoor and P. Bisignano and A. Gupta and M. Mezei and S. Kumar and M. Filizola and L. Devi},
  journal={Science Signaling},
  year={2016},
  volume={9},
  pages={ra55 - ra55}
}
Stimulation of the receptor GPR171 with a small-molecule ligand results in hyperphagia and weight gain in mice. Discovering chemicals that control appetite Understanding the signals that control hunger and food intake is important given the global increase in metabolic disease. The neuropeptide b-LEN and its receptor GPR171 regulate food intake in mice. Wardman et al. used structural modeling and virtual molecule docking to identify candidate chemical ligands for GPR171. One of these, MS0015203… Expand
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