Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

Abstract

Proteins containing PSD-95/Discs-large/ZO-1 homology (PDZ) domains play key roles in the assembly and regulation of cellular signaling pathways and represent putative targets for new pharmacotherapeutics. Here we describe the first small-molecule inhibitor (FSC231) of the PDZ domain in protein interacting with C kinase 1 (PICK1) identified by a screening of… (More)
DOI: 10.1073/pnas.0902225107

Topics

4 Figures and Tables

Cite this paper

@article{Thorsen2010IdentificationOA, title={Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.}, author={Thor Seneca Thorsen and Kenneth L Madsen and Nelson Rebola and Mette Rathje and Victor Anggono and Anders Bach and Irina S. Moreira and Nicolai Stuhr-Hansen and Tino Dyhring and Dan Peters and Thijs Beuming and Richard L. Huganir and Harel Weinstein and Christophe Mulle and Kristian Str\omgaard and Lars Christian Biilmann R\onn and Ulrik Gether}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 1}, pages={413-8} }