Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.

Abstract

Small GTPases are key regulators of cellular activity and represent novel targets for the treatment of human diseases using small-molecule inhibitors. The authors describe a multiplex, flow cytometry bead-based assay for the identification and characterization of inhibitors or activators of small GTPases. Six different glutathione-S-transferase (GST)-tagged… (More)
DOI: 10.1177/1087057109352240

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