Identification of a signature motif in target mRNAs of RNA-binding protein AUF1

@inproceedings{MazanMamczarz2009IdentificationOA,
  title={Identification of a signature motif in target mRNAs of RNA-binding protein AUF1},
  author={Krystyna Mazan-Mamczarz and Yuki Kuwano and Ming Zhan and Elizabeth Jayne White and Jennifer L Martindale and Ashish Lal and Myriam Gorospe},
  booktitle={Nucleic acids research},
  year={2009}
}
The ubiquitous RNA-binding protein AUF1 promotes the degradation of some target mRNAs, but increases the stability and translation of other targets. Here, we isolated AUF1-associated mRNAs by immunoprecipitation of (AUF1-RNA) ribonucleoprotein (RNP) complexes from HeLa cells, identified them using microarrays, and used them to elucidate a signature motif shared among AUF1 target transcripts. The predicted AUF1 motif (29-39 nucleotides) contained 79% As and Us, consistent with the AU-rich… CONTINUE READING

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