Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2).

@article{Parkhurst1998IdentificationOA,
  title={Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2).},
  author={Maria R. Parkhurst and Ellen B. Fitzgerald and Scott Southwood and Alessandro Sette and Steven A Rosenberg and Yosuke Kawakami},
  journal={Cancer research},
  year={1998},
  volume={58 21},
  pages={
          4895-901
        }
}
Tyrosinase-related protein 2 (TRP2) is a melanosomal enzyme expressed in most mammalian melanocytes and melanomas. This protein has been identified as a melanoma antigen recognized by tumor reactive CTLs derived from tumor infiltrating lymphocytes in the context of HLA-A31 and HLA-A33. The frequencies of these HLA-A alleles among melanoma patients in the United States is low (approximately 6% for HLA-A31 and approximately 2% for HLA-A33) compared with that of HLA-A*0201 (approximately 46… CONTINUE READING

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