Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.

Abstract

BACKGROUND AND PURPOSE High-fat diet consumption results in obesity and chronic low-grade inflammation in adipose tissue. Whereas glucocorticoid receptor (GR) antagonism reduces diet-induced obesity, GR agonism reduces inflammation, the combination of which would be desired in a strategy to combat the metabolic syndrome. The purpose of this study was to… (More)
DOI: 10.1111/bph.13477

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