Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2

@article{Groth2002IdentificationOA,
  title={Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2},
  author={Casper Groth and Svanhild Nornes and R. McCarty and Richard Tamme and Michael T. Lardelli},
  journal={Development Genes and Evolution},
  year={2002},
  volume={212},
  pages={486-490}
}
Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression… CONTINUE READING

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