Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

@article{Xing2016IdentificationOA,
  title={Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract},
  author={Junji Xing and Leiyun Weng and Bin Yuan and Zhuo Wang and Li Jia and Rui Jin and Hongbo Lu and Xian Chang Li and Yong-Jun Liu and Zhiqiang Zhang},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={1373-1380}
}
The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while… CONTINUE READING
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