Identification of a retinoic acid-responsive neural enhancer in the Ciona intestinalis Hox1 gene.


The Hox1 gene in the urochordate ascidian Ciona intestinalis (Ci-Hox1) is expressed in the nerve cord and epidermis. We identified a nerve cord enhancer in the second intron of Ci-Hox1, and demonstrated that retinoic acid (RA) plays a major role in activating this enhancer. The enhancer contained a putative retinoic acid-response element (RARE). Mutation of… (More)
DOI: 10.1111/dgd.12033