Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

@article{Freeman1995IdentificationOA,
  title={Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.},
  author={Brian C. Freeman and Michael P. Myers and Reto Schumacher and Richard I. Morimoto},
  journal={The EMBO journal},
  year={1995},
  volume={14 10},
  pages={2281-92}
}
The Hsp70 family of molecular chaperones has an essential role in the synthesis, folding and translocation of the nascent peptide chain. While the general features of these activities are well documented, less is understood about the regulation of these activities. The ATPase rate is stimulated by non-native proteins, furthermore, interaction with ATP leads to the release of protein substrate concurrent with a conformational change in Hsp70. One interpretation of these data is that the two… CONTINUE READING
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