Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.

@article{Hallen2002IdentificationOA,
  title={Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor.},
  author={Stefan Hallen and Anna Bj{\"o}rquist and Ann-Margret Ostlund-Lindqvist and George b. Sachs},
  journal={Biochemistry},
  year={2002},
  volume={41 50},
  pages={
          14916-24
        }
}
Drug intervention that prevents reabsorption of circulating bile acids by the apical (ileal) sodium/bile acid cotransporter (ASBT) may be a promising new therapy for lowering of plasma cholesterol. 2164U90 is a benzothiazepine-based competitive inhibitor of bile acid transport with K(i) values of approximately 10 and 0.068 microM for the homologous human and mouse apical transporters, respectively. Hybrid human-mouse and mouse-human transporters were engineered to identify regions involved in… CONTINUE READING
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