Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer.

@article{Zhang2006IdentificationOA,
  title={Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer.},
  author={Lizhi Zhang and Li Chenwei and Redah Mahmood and Kenneth L. van Golen and Joel Greenson and Gangyong Li and Nisha J D'silva and Xiangquan Li and Charles F. Burant and Craig D. Logsdon and Diane M Simeone},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={898-906}
}
Human chromosome 1p35-p36 has long been suspected to harbor a tumor suppressor gene in pancreatic cancer and other tumors. We found that expression of rap1GAP, a gene located in this chromosomal region, is significantly down-regulated in pancreatic cancer. Only a small percentage of preneoplastic pancreatic intraductal neoplasia lesions lost rap1GAP expression, whereas loss of rap1GAP expression occurred in 60% of invasive pancreatic cancers, suggesting that rap1GAP contributes to pancreatic… CONTINUE READING

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Human SPA-1 gene product selectively expressed in lymphoid tissues Rap1GAP in Pancreatic Cancer www.aacrjournals.org

  • H Kurachi, Y Wada, N Tsukamoto
  • Cancer Res
  • 2006
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