Identification of a putative Syp substrate, the PDGF beta receptor.

  title={Identification of a putative Syp substrate, the PDGF beta receptor.},
  author={Richard A. Klinghoffer and Andrius Kazlauskas},
  journal={The Journal of biological chemistry},
  volume={270 38},
Because the protein-tyrosine phosphatase (PTP) Syp associates with the tyrosine-phosphorylated platelet-derived growth factor beta receptor (beta PDGFR), the beta PDGFR is a likely Syp substrate. We tested this hypothesis by determining whether recombinant Syp (rSyp) and a control PTP, recombinant PTP1B (rPTP1B), were able to dephosphorylate the beta PDGFR. The beta PDGFR was phosphorylated at multiple tyrosine residues in an in vitro kinase assay and then incubated with increasing… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…