Identification of a protein mediating respiratory supercomplex stability.

@article{Chen2012IdentificationOA,
  title={Identification of a protein mediating respiratory supercomplex stability.},
  author={Yu-Chan Chen and Eric B. Taylor and Noah Dephoure and Jin-Mi Heo and Aline Tonhato and Ioanna Papandreou and Nandita Nath and Nicolas C Denko and Steven P Gygi and Jared Rutter},
  journal={Cell metabolism},
  year={2012},
  volume={15 3},
  pages={348-60}
}
The complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow. We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory supercomplexes. We demonstrate that Rcf1 stably and independently associates with both Complex III and Complex IV of the electron transport chain. Deletion of the RCF1 gene caused… CONTINUE READING

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