Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.

@article{Darnay1994IdentificationOA,
  title={Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.},
  author={Bryant G. Darnay and Shrikanth A. G. Reddy and Bharat Bhushan Aggarwal},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 32},
  pages={20299-304}
}
Tumor necrosis factor (TNF) has been shown to bind two distinct receptors, designated p60 and p80, with high affinity, resulting, within minutes, in phosphorylation of several proteins. The receptors themselves do not exhibit protein kinase activity nor have any associated proteins been identified. We employed the glutathione-S-transferase (GST) fusion protein system consisting of the cytoplasmic domain of p60 (GST-p60CD delta 1) as a probe to help us identify receptor-associated proteins from… CONTINUE READING

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