Identification of a potential topoisomerase II “hotspot” DNA region in the DEK gene in two t(6;9)-positive therapy-related myeloid neoplasms

@article{Piredda2016IdentificationOA,
  title={Identification of a potential topoisomerase II “hotspot” DNA region in the DEK gene in two t(6;9)-positive therapy-related myeloid neoplasms},
  author={Maria Liliana Piredda and Gianfranco Catalano and Claudia Ciardi and Mariadomenica Divona and Laura Cicconi and Paola Panetta and Paola Curzi and Eduardo Garza and Carmen Mart{\'i}nez-Losada and Massimiliano Postorino and Francesco Lo-Coco and N I Noguera},
  journal={Annals of Hematology},
  year={2016},
  volume={96},
  pages={155-157}
}
Dear Editor, DEK/NUP214 is considered the unique product of the translocation t(6;9)(p22;q34), first identified in 1976 and described in 1992 by von Lindern [1]. Relatively rare (1–5 % of adult AML and <1% of childhood AML), it has been reported also in AML secondary to MDS and in therapy-related myeloid neoplasms (t-MN), defines a high-risk group [2], and is frequently associated to FLT3-ITDmutation (80%) [3]. We analyzed the DEK and NUP214 breakpoint sequences in two patients who developed… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 10 REFERENCES