Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.

@article{Graves1991IdentificationOA,
  title={Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.},
  author={Rochelle A. Graves and Peter Tontonoz and Susan R Ross and Bruce M. Spiegelman},
  journal={Genes & development},
  year={1991},
  volume={5 3},
  pages={428-37}
}
The molecular basis for adipocyte-specific gene expression is not known. We have demonstrated that while short (-168) segments of the 5'-flanking sequence of the adipocyte P2 gene containing AP-1- and C/EBP-binding sites can direct expression of a heterologous gene in cultured adipocytes, they cannot support tissue-specific expression in a transgenic mouse. We have therefore analyzed larger segments of the aP2 5'-flanking region by transfection into adipocytes and have found an enhancer at -5.4… CONTINUE READING

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