Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.

@article{Martin2014IdentificationOA,
  title={Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.},
  author={Dale David Orr Martin and Ryan J Heit and M. C. FALANRUW Yap and Michael W. Davidson and Michael R. Hayden and Luc G{\'e}rard Berthiaume},
  journal={Human molecular genetics},
  year={2014},
  volume={23 12},
  pages={3166-79}
}
Huntington disease (HD) is a debilitating neurodegenerative disease characterized by the loss of motor control and cognitive ability that ultimately leads to death. It is caused by the expansion of a polyglutamine tract in the huntingtin (HTT) protein, which leads to aggregation of the protein and eventually cellular death. Both the wild-type and mutant form of the protein are highly regulated by post-translational modifications including proteolysis, palmitoylation and phosphorylation. We now… CONTINUE READING
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