Identification of a post-targeting step required for efficient cotranslational translocation of proteins across the Escherichia coli inner membrane.

@article{Tian2009IdentificationOA,
  title={Identification of a post-targeting step required for efficient cotranslational translocation of proteins across the Escherichia coli inner membrane.},
  author={Pu Tian and Harris D Bernstein},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 17},
  pages={11396-404}
}
Recent studies have shown that cytoplasmic proteins are exported efficiently in Escherichia coli only if they are attached to signal peptides that are recognized by the signal recognition particle and are thereby targeted to the SecYEG complex cotranslationally. The evidence suggests that the entry of these proteins into the secretory pathway at an early stage of translation is necessary to prevent them from folding into a translocation-incompetent conformation. We found, however, that several… CONTINUE READING
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