Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

Abstract

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is an indicator of poor prognosis in several carcinoma entities, the existence and phenotype of metastasis-initiating cells (MICs) among CTCs has not been experimentally… (More)
DOI: 10.1038/nbt.2576

Topics

5 Figures and Tables

Cite this paper

@article{Baccelli2013IdentificationOA, title={Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay}, author={Ir{\`e}ne Baccelli and Andreas Schneeweiss and Sabine Riethdorf and Albrecht Stenzinger and Anja Schillert and Vanessa Vogel and Corinna Klein and Massimo Saini and Tobias Baeuerle and Markus Wallwiener and Tim Holland-Letz and Thomas Hoefner and Martin R Sprick and Martina Scharpff and Frederik Marme and Hans Peter Sinn and Klaus Pantel and Wilko Weichert and Andreas Trumpp}, journal={Nature Biotechnology}, year={2013}, volume={31}, pages={539-544} }