Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant cattle tick.

@article{He1999IdentificationOA,
  title={Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant cattle tick.},
  author={Haiqi He and Andrew C. Chen and Ronald B. Davey and G. Wayne Ivie and John Edward George},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 3},
  pages={558-61}
}
To investigate the molecular mechanism of resistance to pyrethroids in the southern cattle tick, Boophilus microplus, we have obtained and sequenced a partial para-homologous sodium channel cDNA from susceptible and pyrethroid-resistant tick strains. A point mutation that results in an amino acid change from Phe to Ile was identified in the highly conserved domain IIIS6 of the homologous sodium channel from ticks that are highly resistant to pyrethroid acaricides. This mutation is at a location… CONTINUE READING
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