Identification of a phospholipase C beta subtype in rat taste cells.

@article{Roessler1998IdentificationOA,
  title={Identification of a phospholipase C beta subtype in rat taste cells.},
  author={Patricia Roessler and C Kroner and Joachim Freitag and J No{\'e} and Heinz Breer},
  journal={European journal of cell biology},
  year={1998},
  volume={77 3},
  pages={
          253-61
        }
}
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198 Citations
Highly Influential Citations
13
Background Citations
91
Methods Citations
5

198 Citations

Phospholipase C-beta 2 as a mammalian taste signaling marker is expressed in the multiple gustatory tissues of medaka fish, Oryzias latipes
Expression of Prostatic Acid Phosphatase in Rat Circumvallate Papillae
TLDR
Examination of the expression profile of PAP in rat taste buds suggests that PAP expressed by type I and one of type III taste cells of rats may contribute to metabolic regulation of the extracellular levels of adenine nucleotides in the taste buds of circumvallate papillae, and the regulating mechanisms for adenines nucleotide in taste buds might be different between rats and mice.
Co-expression of calcium signaling components in vertebrate taste bud cells
Characterization of umami receptor and coupling G protein in mouse taste cells
TLDR
It is demonstrated that umami stimuli were received by G protein-coupled receptors that function together with some of the G&agr;i family members.
Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
TLDR
IP3R3 is the dominant form of the IP3 receptor expressed in taste cells and the data suggest it plays an important role in bitter taste transduction.
Group IIA phospholipase A2 is coexpressed with SNAP‐25 in mature taste receptor cells of rat circumvallate papillae
TLDR
In situ hybridization analysis indicated that group IIA phospholipase A2 (PLA2‐IIA) is expressed in a subset of taste bud cells.
Umami Responses in Mouse Taste Cells Indicate More than One Receptor
TLDR
Using pharmacological agents, ion substitution, and immunostaining, it is shown that intracellular pathways downstream of receptor activation involve phospholipase C β2, and each of the above features matches those predicted by studies of cloned and expressed receptors.
A transient receptor potential channel expressed in taste receptor cells
TLDR
Heterologous expression studies of Trpm5 indicate that it functions as a cationic channel that is gated when internal calcium stores are depleted, and may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds.
Expression of phospholipase C-beta4 in rat circumvallate taste buds.
TLDR
The expression patterns of mGluR1α and taste signaling molecules, Gαq and PLCβ2 in rat circumvallate papillae and taste buds are examined for the first time and it is deduced that PLC-β4 might contribute the mGLUR1-mediated signal transduction in taste sensation.
G Protein βγ Complexes in Circumvallate Taste Cells Involved in Bitter Transduction
TLDR
Data support the concept that the denatonium benzoate-induced IP 3 response is mediated by an activation of PLCβ 2 via a Gβγ complex, possibly composed of Gβ 3 as the predominant β subunit and Gγ 3 , and imply that multiple second messenger pathways may exist in individual taste receptor cells.
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References

SHOWING 1-10 OF 37 REFERENCES
Generation of inositol phosphates in bitter taste transduction
Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.
TLDR
Evidence for a role of phosphatidylinositol turnover in bitter taste is the observation of a rapid, selective increase in mass levels of inositol 1,4,5-trisphosphate elicited by low concentrations of denatonium, a potently bitter tastant.
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits.
Gustducin is a taste-cell-specific G protein closely related to the transducins
A novel G protein α-subunit (α-gustducin) has been identified and cloned from taste tissue, α-Gustducin messenger RNA is expressed in taste buds of all taste papillae (circumvallate, foliate and…
Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells
TLDR
It is suggested that rod transducin tranduces bitter taste by coupling taste receptor(s) to taste-cell phosphodiesterase through the recently identified cyclic-nucleotide-suppressible conductance.
A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells.
TLDR
The transduction of bitter taste may occur via a receptor-second messenger mechanism leading to neurotransmitter release and may not involve depolarization-mediated calcium entry.
Rapid kinetics of second messenger production in bitter taste.
TLDR
The rapid kinetics, transient nature, and specificity of the bitter taste stimulus-induced IP3 formation are consistent with the role of IP3 as a second messenger in the chemoelectrical transduction of bitter taste.
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits
TLDR
PLC-β1 and P LC-β2 were stimulated by free βγ subunits and that PLC- β2 was the most sensitive to βγ stimulation, which indicates stimulation of PLC by βγSubunits is isozyme-selective and PLC -β2 is a prime target of βγ stimulated cells.
Transduction of bitter and sweet taste by gustducin
TLDR
Gustducin is a principal mediator of both bitter and sweet signal transduction, and its role in taste transduction is investigated by generating and characterizing mice deficient in the gustducin α-subunit.
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