Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

  title={Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.},
  author={Christophe J Desmet and Tristan Gallenne and Alexandre Prieur and Fabien Reyal and N. C. Link Visser and Ben S. Wittner and Marjon A. Smit and Thomas R. Geiger and Jamila Laoukili and Sedef Iskit and Boris Rodenko and Wilbert Zwart and Bastiaan Evers and Hugo M. Horlings and Abderrahrim Ajouaou and John Zevenhoven and Martin van Vliet and Sridhar Ramaswamy and Lodewyk F. A. Wessels and Daniel S Peeper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 13},
Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are key signal integrators connecting cellular processes to clinical outcome, we aimed to identify transcriptional nodes regulating cancer cell metastasis. Using rodent xenograft models that we previously developed, we identified the transcription factor Fos-related antigen-1 (Fra-1) as a key coordinator of metastasis. Because Fra-1 often is… CONTINUE READING
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