Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.

@article{Ottaviani2009IdentificationOA,
  title={Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.},
  author={Alexandre Ottaviani and Caroline Schluth-Bolard and Sylvie Rival-Gervier and Amina Boussouar and Delphine Rondier and Andrea Maria Foerster and Julia Morere and Serge Bauwens and Sophie Gazzo and Evelyne Callet-Bauchu and Eric Gilson and Fr{\'e}d{\'e}rique Magdinier},
  journal={The EMBO journal},
  year={2009},
  volume={28 16},
  pages={2428-36}
}
The localization of genes within the nuclear space is of paramount importance for proper genome functions. However, very little is known on the cis-acting elements determining subnuclear positioning of chromosome segments. We show here that the D4Z4 human subtelomeric repeat localizes a telomere at the nuclear periphery. This perinuclear activity lies within an 80 bp sequence included within a region known to interact with CTCF and A-type Lamins. We further show that a reduced level of either… CONTINUE READING

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