Identification of a p53-dependent negative response element in the bcl-2 gene.

  title={Identification of a p53-dependent negative response element in the bcl-2 gene.},
  author={Toshiyuki Miyashita and Masayoshi Harigai and Masuo Hanada and John C. Reed},
  journal={Cancer research},
  volume={54 12},
Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene. In this report, we explored the molecular basis for p53-mediated down-regulation of bcl-2 gene expression using a cotransfection approach involving p53 expression plasmids and chloramphenicol acetyltransferase (CAT) reporter gene constructs containing regions from the bcl-2 gene. When transfected into a p53-deficient human lung cancer cell line H358, reporter gene constructs containing… CONTINUE READING
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Functional domains of wild-type andmutantp53proteinsinvolvedin transcriptional regulation,transdominant inhi bition, and transformation suppression

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