Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.

@article{Osifchin1994IdentificationOA,
  title={Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.},
  author={N E Osifchin and Di Jiang and N Ohtani-Fujita and Takeshi Fujita and M Carroza and Soo Jung Kim and Toshiyuki Sakai and P. David Robbins},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 9},
  pages={6383-9}
}
p53 is a tumor suppressor gene found to be mutated in a wide variety of tumors. The encoded p53 protein has properties of a classical transcription factor, but the promoter targets for its regulation are largely unknown. We have investigated the ability of p53 to regulate activity of the human retinoblastoma susceptibility gene (Rb) promoter using a cotransfection assay in CCL-64 and Saos-2 cells. p53 was able to stimulate transcription from the Rb promoter at low input doses of p53 expression… CONTINUE READING

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