Identification of a novel type 1 diabetes susceptibility gene, T-bet

  title={Identification of a novel type 1 diabetes susceptibility gene, T-bet},
  author={Yuka Sasaki and Kenji Ihara and Nobuo Matsuura and Hitoshi Kohno and Seiho Nagafuchi and Ryuichi Kuromaru and Koichi Kusuhara and Ryu Takeya and Timothy Hoey and Hideki Sumimoto and Toshiro Hara},
  journal={Human Genetics},
The gene encoding interferon (IFN)-γ, IFNG, is known as one of the candidate susceptibility genes for type 1 diabetes. In addition, cytokines, including IFN-γ, play important roles in the pathogenesis of type 1 diabetes. Therefore, we focused on the Th1-specific T-box transcription factor gene (T-bet), which contributes to the induction of the hallmark Th1 cytokine, IFN-γ. We first screened for polymorphisms in the T-bet gene and detected two microsatellite repeat polymorphisms located in… CONTINUE READING
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