Identification of a novel transcriptional regulatory element common to the p53 and interferon regulatory factor 1 genes.

@article{Lallemand1997IdentificationOA,
  title={Identification of a novel transcriptional regulatory element common to the p53 and interferon regulatory factor 1 genes.},
  author={Christophe Lallemand and M Bayat-Sarmadi and B. Blanchard and Michael G Tovey},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 47},
  pages={29801-9}
}
The promoter regions of both the interferon regulatory factor (IRF1) and p53 antioncogenes contain a previously unidentified sequence denoted IRF1 p53 common sequence (IPCS), which markedly increases the transcriptional activity of a reporter gene placed under the control of an heterologous promoter in transfected U937 cells. In contrast, transfection of U937 cells with reporter vectors containing p53 and IRF1 promoters with mutated IPCS sites resulted in a 4-fold reduction in the constitutive… CONTINUE READING