Identification of a novel thrombin receptor sequence required for activation-dependent responses.

@article{Bahou1994IdentificationOA,
  title={Identification of a novel thrombin receptor sequence required for activation-dependent responses.},
  author={Wadie F. Bahou and Jeffrey L. Kutok and Amanda W T Wong and Charlie Potter and Barry S. Coller},
  journal={Blood},
  year={1994},
  volume={84 12},
  pages={4195-202}
}
Thrombin receptor (TR) activation by alpha-thrombin requires proteolytic cleavage, although synthetic peptides modeled after the new N-terminus directly effect receptor activation without cleavage, presumably by interacting with an unidentified region of the receptor. To further define critical residues responsible for receptor activation, we performed epitope mapping of anti-TR1-160, a previously described polyclonal antibody that inhibits peptide ligand-induced receptor activation in various… CONTINUE READING

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Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

  • RE Gerstzen, 1 ChenJ, +6 authors Coughlin
  • Nature
  • 1994

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