Identification of a novel temperature sensitive promoter in cho cells

  title={Identification of a novel temperature sensitive promoter in cho cells},
  author={Haruthai Thaisuchat and Martina Baumann and Jens Pontiller and Friedemann Hesse and Wolfgang Ernst},
  booktitle={BMC biotechnology},
BACKGROUND The Chinese hamster ovary (CHO) expression system is the leading production platform for manufacturing biopharmaceuticals for the treatment of numerous human diseases. Efforts to optimize the production process also include the genetic construct encoding the therapeutic gene. Here we report about the successful identification of an endogenous highly active gene promoter obtained from CHO cells which shows conditionally inducible gene expression at reduced temperature. RESULTS Based… CONTINUE READING
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