Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.

@article{Kim2002IdentificationOA,
  title={Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.},
  author={Kevin B Kim and Reuben Lotan and Ping Yue and Michael B. Sporn and Nanjoo Suh and Gordon W. Gribble and Tadashi Honda and Gen Sheng Wu and Waun Ki Hong and Shi-yong R Sun},
  journal={Molecular cancer therapeutics},
  year={2002},
  volume={1 3},
  pages={177-84}
}
Lung cancer continues to be the leading cause of cancer-related death in the United States. Therefore, new agents targeting prevention and treatment of lung cancer are urgently needed. In the present study, we demonstrate that a novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) is a potent inducer of apoptosis in human… CONTINUE READING