Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz.

@article{Wang2006IdentificationOA,
  title={Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz.},
  author={Jue Wang and Anders S{\"o}nnerborg and Anders Rane and Filip Josephson and Stefan Lundgren and Lars St{\aa}hle and Magnus Ingelman-Sundberg},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 3},
  pages={
          191-8
        }
}
The non-nucleoside reverse transcriptase inhibitor efavirenz is mainly metabolised by the polymorphic cytochrome P450 enzyme CYP2B6. Genomic DNA from four subjects in a group of 51 patients being treated with efavirenz and having surprisingly high plasma concentrations were screened by direct sequencing for mutations in the CYP2B6 gene. Four exonic single nucleotide polymorphisms (SNPs), 516G > T, 714G > A, 785A > G and 983T > C, and eight intronic SNPs were identified. Haplotype analysis… CONTINUE READING
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